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Due to the greater effect on systolic than on diastolic blood pressure, thiazides lower pulse pressure by 4 mmHg to 6 mmHg. This exceeds the mean 3 mmHg pulse pressure reduction achieved by ACE inhibitors, ARBs and renin inhibitors, and the 2 mmHg pulse pressure reduction with non-selective beta-blockers as shown in other Cochrane reviews. 2009: ABSTRACT: When modern antihypertensive drugs cost far more than the old and tried, and have around 40 risk of adverse effects (Girerd 2002 Paris), and give inferior risk reduction, it is unethical for routine hypertension patients initially to be prescribed modern drugs singly or in combination in uncomplicated cases before trying the gold standard old risk-free lowdose reserpine-amilozide combination. 2009 has been a landmark year of published studies on first-line hypertension treatment.

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