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Does the early redstart twittering. through the woods. Do I astonish more than they.

Why would BMS and Merck delay publication of this trial for so many years, and blatantly deny knowledge of it after the first report of the trial result at a USA diabetes congress. The answer can only be the predicted- because it confirmed in the biggest metformn trial cohort ever- 8000 patient-years- that metformin in diabetics gave zero significant adverse drug effects, with the all-cause deathrate in fact 9 lower than in those on other conventional antidiabetic therapies; and four major diabetes prevention trials of metformin in four continents confirmed that it at least halves the incidence of new diabetes- with zero significant adverse effects; and in the intervening years between this trial and it8217;s result publication, both BMS and Merck developed and launched their respective combinations of metformin and a sulphonylurea (M SU). This despite the fact that it was clear since at least the 1970s that the addition of sulphonylurea to metformin is a desperate last resort since it is fraught with risk of hypoglycemia and reversal of the reduction in fatness produced by metformin alone. A new retrospective study just published from the UK patient database confirms the folly known all along of combination of SU with metformin in that that over a mean of 4 years on therapy, the metforminSU therapy reduced all-cause mortality by 23 compared to SU alone; while metformin alone compared to SU alone reduced mortality 13 more ie by 30 8211; with trivial risk of hypoglycemia. This was similar to the outcome in the 20year UKPDS RCT, where metformin reduced all-cause mortality by 36 over a mean of 13 years, making it the safest and most effective drug ever patented for chronic degenerative disease. And note the cynical folly of the many manufacturers of the grossly overpromoted and overprescribed bisphosphonates and statins 8211; which have numerous serious adverse effects and should be last-ditch therapy in metastatic bone cancer and in rare serious hyperlipidemia, not for osteoporosis, not for mild to moderate lipidemia and certainly not over-the-counter as profiteers crave.

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