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The city was founded on September 4,1781, by Spanish governor Felipe de Neve. It became a part of Mexico in 1821 following the Mexican War of Independence, in 1848, at the end of the Mexican釧merican War, Los Angeles and the rest of California were purchased as part of the Treaty of Guadalupe Hidalgo, thereby becoming part of the United States. Los Angeles was incorporated as a municipality on April 4,1850, the discovery of oil in the 1890s brought rapid growth to the city. The completion of the Los Angeles Aqueduct in 1913, delivering water from Eastern California, nicknamed the City of Angels, Los Angeles is known for its Mediterranean climate, ethnic diversity, and sprawling metropolis.

ENDURINGLY BENEFICIAL MODERN CHRONIC DRUGS: The above drugs contrast with vey few modern chronic designer drugs that are still the leaders in their fields, whether as original or generic 8211; although none of them has been shown to address all-cause mortality and pathogenesis. Pfizer8217;s Norvascamlodipine is a rare modern designer exception 8211; dating from the late 1980s, it8217;s patent has only just run out- proving it8217;s enduring worth for longterm hypertension therapy as the premier 4th-line drug to add when reserpine 0. 125mg plus amiloretic 12 (ie HCT 25mg amiloride 2. 5mg) daily are inadequate for optimal control; with very low risk of serious adverse effects. BMS8217; Captopril amp; Merck 8216;s Renitec 8211; angiotensin converting enzyme inhibitors ACEI 8211; date from the mid-late 8217;70s, and while they were and are the first of the invaluable ACEI inhibitors, 5th line antihypertensive drugs for common use, they have formidable potential for lifethreatening adverse effects- but they are on essential drug lists. In the past dozen years big pharma has attempted to substitute angiotensin 11 receptor blockers ARBs, for the aging ACEI, but a recent metanalysis shows that neither group of drugs significantly lowers fatal or nonfatal cardiovascular events- and they all (unlike reserpine coamiloretic amlodipine) have risk of life-threatening adverse effects.

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